Selected publications:

Ghazizadeh Z, Kiviniemi TO, Olafsson S, Plotnick D, Beerens M, Zhang K, Gillon L, Steinbaugh M, Barrera V, Ho Sui S, Werdich AA, Kapur S, Eranti A, Gunn J, Jalkanen J, Airaksinen J, Kleber AG, Hollmén M, MacRae CA.

A Metastable Atrial State Underlies The Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation.

Circulation. 2019 Nov 16. doi: 10.1161/CIRCULATIONAHA.119.044268. (fast track)

Kiviniemi TO, Kc A, Chiang DY, Teramoto R, Buys E, Kelly AE, George WA, Ghazizadeh Z, Relander A, Gunn J, Hollmén M, Beerens M, MacRae CA.

CELL POLARITY ABNORMALITIES CHARACTERIZE THE PREARRHYTHMIC SUBSTRATE FOR ATRIAL FIBRILLATION

Submitted

Suvi Linna-Kuosmanen, Eloi Schmauch, Kyriakitsa Galani, Carles A. Boix, Lei Hou, Tiit Örd, Anu Toropainen, Lindsey K. Stolze, Elamaran Meibalan, Julio C. Mantero, Ashley Renfro, Johannes Ojanen, Leandro Z. Agudelo, Maija Hollmen, Juho Jalkanen, Jarmo Gunn, Pasi Tavi, Casey E. Romanoski, Calum A. MacRae, Minna U. Kaikkonen, Guillermo Garcia-Cardena, Tuomas Kiviniemi, Manolis Kellis

SINGLE-CELL DISSECTION OF LIVE HUMAN HEARTS IN ISCHEMIC HEART DISEASE AND HEART FAILURE REVEALS CELL-TYPE-SPECIFIC DRIVERGENES AND PATHWAYS

bioRxiv, https://doi.org/10.1101/2021.06.23.449672

Viikinkoski E, Jalkanen J, Gunn J, Vasankari T, Lehto J, Valtonen M, Biancari F, Jalkanen S, Airaksinen KEJ, Hollmén M, Kiviniemi TO.

RED BLOOD CELL TRANSFUSION INDUCES ABNORMAL HIF1-A RESPONSE TO CYTOKINE STORM AFTER CARDIAC SURGERY.

Sci Rep. 2021 Nov 15;11(1):22230. doi: 10.1038/s41598-021-01695-4.

Koskinen A, Aittokallio J, Gunn J, Relander A, Viikinkoski E, Vasankari T, Jalkanen J, Hollmen M, Kiviniemi TO.

DISADVANTAGES OF HIGH FLUID INFUSION RATE IN CARDIAC SURGERY.

Eur J Anaesthesiol. 2022 Dec 1;39(12):963-966. doi: 10.1097/EJA.0000000000001764

Lehto J, Gunn J, Björn R, Malmberg M, Airaksinen KEJ, Kytö V, Nieminen T, Hartikainen J, Biancari F, Kiviniemi TO.

ADverse events and survival with postpericardiotomy syndrome after aortic valve replacement.

J Thorac Cardiovasc Surg. 2020 Jan 28:S0022-5223(20)30231-2. doi: 10.1016/j.jtcvs.2019.12.114. PMID: 32107032.

Hayashi K, Teramoto R, Nomura A, Asano Y, Beerens M, Kurata Y, Kobayashi I, Fujino N, Furusho H, Sakata K, Onoue K, Chiang DY, Kiviniemi TO, Buys E, Sips P, Burch ML, Zhao Y, Kelly AE, Namura M, Kita Y, Tsuchiya T, Kaku B, Oe K, Takeda Y, Konno T, Inoue M, Fujita T, Kato T, Funada A, Tada H, Hodatsu A, Nakanishi C, Sakamoto Y, Tsuda T, Nagata Y, Tanaka Y, Okada H, Usuda K, Cui S, Saito Y, MacRae CA, Takashima S, Yamagishi M, Kawashiri MA, Takamura M.

Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases.

Cardiovasc Res. 2020 Jan 24. pii: cvaa010. doi: 10.1093/cvr/cvaa010. (in press)

Nissinen M, Lehto J, Biancari F, Nieminen T, Malmberg M, Yannopoulos F, Salmi S, Airaksinen KEJ, Kiviniemi TO and Hartikainen J.

ADverse PREoperative paroxysmal atrial fibrillation predicts high cardiovascular mortality in patients undergoing surgical aortic valve replacement with a bioprosthesis - careavr study

Clin Cardiol. 2020 Apr;43(4):401-409. doi: 10.1002/clc.23329.

Kiviniemi TO

Evolving field of LONG-TERM anticoagulation therapy after percutaneous coronary intervention in Patients with Atrial Fibrillation

The American Journal of Medial Sciences 2019: Volume 358, Issue 2, Pages 91–92.

Kaisti M, Panula T, Leppänen J, Punkkinen R, Jafari Tadi M, Vasankari T, Jaakkola S, Kiviniemi T, Airaksinen J, Kostiainen P, Meriheinä U, Koivisto T, Pänkäälä M.

Clinical assessment of a non-invasive wearable MEMS pressure sensor array for monitoring of arterial pulse waveform, heart rate and detection of atrial fibrillation.

NPJ Digit Med. 2019 May 14;2:39. doi: 10.1038/s41746-019-0117-x.

Lehto J, Kiviniemi T, Gunn J, Airaksinen J, Rautava P, Kytö V.

Occurrence of Postpericardiotomy Syndrome: Association With Operation Type and Postoperative Mortality After Open-Heart Operations.

J Am Heart Assoc. 2018 Nov 20;7(22):e010269. doi: 10.1161/JAHA.118.010269.

Jaakkola S, Kiviniemi TO, Airaksinen KEJ.

Cardioversion for atrial fibrillation - how to prevent thromboembolic complications?

Ann Med. 2018 Nov;50(7):549-555. doi: 10.1080/07853890.2018.1523552. Epub 2018 Oct 15. Review.

Kiviniemi T, Lehto J, Nissinen M, Nieminen T, Hartikainen J, Malmberg M, Yannopoulos F, Savolainen J, Karjalainen P, Airaksinen KEJ, Rosato S, Biancari F.

Performance of CHA2DS2-VASc score for stroke prediction after surgical aortic valve replacement.

J Thorac Cardiovasc Surg. 2018 Jul 29. pii: S0022-5223(18)32030-0. doi: 10.1016/j.jtcvs.2018.06.096.

Hellman T, Kiviniemi T, Nuotio I, Biancari F, Vasankari T, Hartikainen J, Lehto M, Airaksinen KJ; FinCV Investigators. 

Optimal timing for cardioversion in patients with atrial fibrillation.

Clin Cardiol. 2018 May 26. doi: 10.1002/clc.22986.

Iftikhar Z, Lahdenoja O, Jafari Tadi M, Hurnanen T, Vasankari T, Kiviniemi T, Airaksinen J, Koivisto T, Pänkäälä M. 

Multiclass Classifier based Cardiovascular Condition Detection Using Smartphone Mechanocardiography.

Sci Rep. 2018 Jun 19;8(1):9344. doi: 10.1038/s41598-018-27683-9.

 Kiviniemi TO, Malmberg M, Biancari F, Hartikainen J, Ihlberg L, Yannopoulos F, Riekkinen T, Lehto J, Nissfolk A, Salmi S, Nissinen M, Airaksinen KEJA, Nieminen T. 

Thromboembolisms related to post-operative electrical cardioversions for atrial fibrillation in patients with surgical aortic valve replacement.

Eur Heart J Qual Care Cardiovasc Outcomes. 2018 Apr 1;4(2):120-125. doi: 10.1093/ehjqcco/qcy003.

Lehto J, Malmberg M, Biancari F, Hartikainen J, Ihlberg L, Yannopoulos F, Riekkinen T, Nissfolk A, Salmi S, Nissinen M, Airaksinen KEJA, Nieminen T, Kiviniemi TO.

Occurrence and classification of cerebrovascular events after isolated bioprosthetic aortic valve replacement - a competing risk analysis of CAREAVR study.

Structural Heart. 2018 2:2;157-63. 

Jaakkola J, Jaakkola S, Lahdenoja O, Hurnanen T, Pänkäälä M, Knuutila T, Kiviniemi TO, Vasankari T, Airaksinen KEJA.

Mobile Phone Detection of Atrial Fibrillation With Mechanocardiography: The MODE-AF Study (Mobile Phone Detection of Atrial Fibrillation).

Circulation. 2018 Apr 3;137(14):1524-1527. doi: 10.1161/CIRCULATIONAHA.117.032804.

Lahtela HM, Bah A, Kiviniemi T, Nammas W, Schlitt A, Rubboli A, Karjalainen PP, Proietti M, Hartikainen JEK, Lip GYH, Airaksinen KEJ.

Outcome of octogenarians with atrial fibrillation undergoing percutaneous coronary intervention: insights from the AFCAS registry.

Clin Cardiol. 2017 Dec 15. doi: 10.1002/clc.22821. [Epub ahead of print] PubMed PMID: 29243834.

Jaakkola S, Nuotio I, Kiviniemi TO, Virtanen R, Virta A, Airaksinen KEJ.

Clinical manifestations and outcomes of severe warfarin overanticoagulation: from the EWA study

Ann Med. 2017 Nov 23:1-8. doi: 10.1080/07853890.2017.1407494. [Epub ahead of print] PubMed PMID: 29156997.

Lautamäki A, Gunn JM, Airaksinen KEJ, Biancari F, Kajander OA, Anttila V, Heikkinen J, Eskola M, Ilveskoski E, Mennander A, Korpilahti K, Wistbacka JO, Kiviniemi TO. 

Permanent work disability in patients ≤50 years old after percutaneous coronary intervention and coronary artery bypass grafting (the CRAGS
study). 

Eur Heart J Qual Care Clin Outcomes. 2017 Apr 1;3(2):101-106. doi: 10.1093/ehjqcco/qcw043. PubMed PMID: 28927176.

Proietti M, Airaksinen KEJ, Rubboli A, Schlitt A, Kiviniemi T, Karjalainen PP, Lip GY; AFCAS Study Group.

Time in therapeutic range and major adverse outcomes in atrial fibrillation patients undergoing percutaneous coronary intervention: The Atrial Fibrillation Undergoing Coronary Artery Stenting (AFCAS) registry.

Am Heart J. 2017 Aug;190:86-93. doi: 10.1016/j.ahj.2017.05.016. Epub 2017 Jun 3.
PubMed PMID: 28760217.

Hellman T, Kiviniemi T, Nuotio I, Vasankari T, Hartikainen J, Lip GYH, Airaksinen KEJ.

Intensity of anticoagulation and risk of thromboembolism after elective cardioversion of atrial fibrillation.

Thromb Res. 2017 Aug;156:163-167. 
doi: 10.1016/j.thromres.2017.06.026. Epub 2017 Jun 22. PubMed PMID: 28662483.

Grönman M, Tarkia M, Kiviniemi T, Halonen P, Kuivanen A, Savunen T, Tolvanen T, Teuho J, Käkelä M, Metsälä O, Pietilä M, Saukko P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A.

maging of α(v)β(3) integrin expression in experimental myocardial ischemia with [(68)Ga]NODAGA-RGD positron emission tomography.

J Transl Med. 2017 Jun 19;15(1):144. doi: 10.1186/s12967-017-1245-1. PubMed PMID: 28629432; PubMed Central PMCID: PMC5477135.

Jaakkola S, Nuotio I, Kiviniemi TO, Virtanen R, Issakoff M, Airaksinen KEJ.

Incidence and predictors of excessive warfarin anticoagulation in patients with atrial fibrillation-The EWA study.

PLoS One. 2017 Apr 20;12(4):e0175975. doi: 10.1371/journal.pone.0175975. eCollection 2017. PubMed PMID: 28426737; PubMed Central PMCID: PMC5398615.

Lahdenoja O, Hurnanen T, Iftikhar Z, Nieminen S, Knuutila T, Saraste A, Kiviniemi T, Vasankari T, Airaksinen J, Pankaala M, Koivisto T.

Fibrillation Detection via Accelerometer and Gyroscope of a Smartphone.

IEEE J Biomed Health Inform. 2018 Jan;22(1):108-118. doi: 10.1109/JBHI.2017.2688473.
Epub 2017 Apr 5. PubMed PMID: 28391210.

Lehtola H, Airaksinen KEJ, Hartikainen P, Hartikainen JEK, Palomäki A, Nuotio I, Ylitalo A, Kiviniemi T, Mustonen P.

Stroke recurrence in patients with atrial fibrillation: concomitant carotid artery stenosis doubles the risk.

Eur J Neurol. 2017 May;24(5):719-725. doi: 10.1111/ene.13280. Epub 2017 Mar 20. PubMed PMID: 28317289.

Pankaala M, Koivisto T, Lahdenoja O, Kiviniemi T, Saraste A, Vasankari T, Airaksinen J.

Detection of atrial fibrillation with seismocardiography.

Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:4369-4374. doi: 10.1109/EMBC.2016.7591695. PubMed PMID: 28269246.

Hellman T, Kiviniemi T, Vasankari T, Nuotio I, Biancari F, Bah A, Hartikainen J, Mäkäräinen M, Airaksinen KE.

Prediction of ineffective elective cardioversion of atrial fibrillation: a retrospective multi-center patient cohort study.

BMC Cardiovasc Disord. 2017 Jan 18;17(1):33. doi: 10.1186/s12872-017-0470-0. PubMed PMID: 28100174; PubMed Central PMCID: PMC5241921.

Proietti M, Airaksinen KEJ, Rubboli A, Schlitt A, Kiviniemi T, Karjalainen PP, Lip GYH; AFCAS Study Group.

Synergic impact of oral anticoagulation control and renal function in determining major adverse events in atrial fibrillation patients undergoing percutaneous coronary intervention: insights from the AFCAS registry.

Clin Res Cardiol. 2017 Jun;106(6):420-427. doi: 10.1007/s00392-016-1071-0. Epub 2017 Jan 11. PubMed PMID: 28078448; PubMed Central PMCID: PMC5442242.

Jaakkola J, Mustonen P, Kiviniemi T, Hartikainen JE, Palomäki A, Hartikainen P, Nuotio I, Ylitalo A, Airaksinen KE.

Stroke as the First Manifestation of Atrial Fibrillation.

PLoS One. 2016 Dec 9;11(12):e0168010. doi: 10.1371/journal.pone.0168010. eCollection 2016. PubMed PMID: 27936187; PubMed Central PMCID: PMC5148080.

Varho V, Nammas W, Kiviniemi TO, Sia J, Romppanen H, Pietilä M, Airaksinen JK, Karjalainen PP.

Comparison of two different sampling intervals for optical coherence tomography evaluation of neointimal healing response after coronary stent implantation.

Int J Cardiol. 2017 Jan 15;227:194-200. doi: 10.1016/j.ijcard.2016.11.173. Epub 2016 Nov 9. PubMed PMID: 27839810.

Hurnanen T, Lehtonen E, Tadi MJ, Kuusela T, Kiviniemi T, Saraste A, Vasankari T, Airaksinen J, Koivisto T, Pankaala M.

Automated Detection of Atrial Fibrillation Based on Time-Frequency Analysis of Seismocardiograms.

IEEE J Biomed Health Inform. 2017 Sep;21(5):1233-1241. doi: 10.1109/JBHI.2016.2621887. Epub 2016 Nov 4. PubMed PMID: 27834656.

Kiviniemi TO, Pietilä A, Gunn JM, Aittokallio JM, Mähönen MS, Salomaa VV, Niiranen TJ.

Trends in rates, patient selection and prognosis of coronary revascularisations in Finland between 1994 and 2013: the CVDR.

EuroIntervention. 2016 Oct 20;12(9):1117-1125. doi: 10.4244/EIJV12I9A183. PubMed PMID: 27753597.

Lehto J, Gunn J, Karjalainen P, Airaksinen J, Kiviniemi T.

Incidence and risk factors of postpericardiotomy syndrome requiring medical attention: The Finlandpostpericardiotomy syndrome study.

 J Thorac Cardiovasc Surg. 2015 May;149(5):1324-9. doi: 10.1016/j.jtcvs.2015.01.031.

Bridging therapy with low molecular weight heparin in patients with atrial fibrillation undergoing percutaneous coronary intervention with stent implantation: the AFCAS study.

Int J Cardiol. 2015 Mar 15;183:105-10. doi: 10.1016/j.ijcard.2015.01.056.

Jalkanen J, Yegutkin GG, Hollmén M, Aalto K, Kiviniemi T, Salomaa V, Jalkanen S, Hakovirta H.

Aberrant circulating levels of purinergic signaling markers are associated with several key aspects of peripheral atherosclerosis and thrombosis. 

Circ Res. 2015 Mar 27;116(7):1206-15. doi: 10.1161/CIRCRESAHA.116.305715.